Synthesis and characterization of amine-functionalized Fe3O4/Mesoporous Silica Nanoparticles (MSNs) as potential nanocarriers in drug delivery systems

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have shown great potential for being utilized in Nanocarriers (NCs) applications throughout the Drug Delivery System (DDS). However, there are several obstacles to make a practical magnetic NCs, such as low dispersity and high toxicity biological systems, also surface area drug loading. In this work, NCs been synthesized through facile three-step process, first SPIONs were by co-precipitation method, then decorated via mesoporous silica finally calcinated functionalized with NH2 simple process ethanol solvent. The structure morphology of as-synthesized characterized usage different analyzing methods XRD, FTIR, TEM, FE-SEM, TGA. Also, properties investigated means VSM each step procedure. Lastly, we applied technique N2 adsorption-desorption observe area, pore size, volume. Besides optimal magnetization final nanoparticles (30 emu/gr), claimed small diameter, at 371 m2.g-1 70 nm, respectively. Moreover, demonstrated well over day PBS solution. As result, as-prepared nanocarrier able overcome delivery used owing its area/ volume, magnetization, condition.